Multivitamin supplementation slowed cognitive decline in older adults COSMOS web research has shown.
Compared with placebo, participants who took a daily multivitamin/multimineral supplement had significantly better self-remembering after 1 year.P=0.025) and on average over 4 years of observation (P= 0.011), reports Adam Brickman, Ph.D. at Columbia University in New York, and co-authors in American Journal of Clinical Nutrition.
The researchers calculated that multivitamins improved memory performance compared to placebo, equivalent to 3.1 years of age-related memory changes. The effect was more pronounced in people with concomitant cardiovascular diseases.
The findings are consistent with data from COSMOS-Mind, another COSMOS subsidiary study, which found that daily multivitamin supplementation resulted in improved cognition, episodic memory, and executive function. The effects of COSMOS-Mind were also more pronounced in people with a history of cardiovascular disease.
“There is evidence that people with cardiovascular disease may have lower micronutrient levels that multivitamins can correct, but we don’t yet know why the effect is stronger in this group,” Brickman said in a statement.
“Supplements of any kind should not replace more holistic ways to get the same micronutrients,” he warned. “While multivitamins are generally safe, people should always check with their doctor before taking them.”
COSMOS-Web was designed to study the effects of flavanol or multivitamin dietary supplements on hippocampal-mediated cognition in older adults at 1 year.
“There is similar evidence that the hippocampus is particularly susceptible to the effects of normal aging, and our previous interventional studies with nutritional supplements have shown positive effects on the hippocampus, indexed by both neuroimaging and neuropsychological assessment,” Brickman and colleagues wrote.
They added that the COSMOS-Web cognitive battery includes neuropsychological outcome measures designed to address the cognitive changes commonly seen in older people.
COSMOS-Web was built into the parent SPACE A trial comparing cocoa flavanol extract with placebo or Centrum Silver daily multivitamin with placebo in people aged 60 years and older. (The authors noted that data for flavanol will be presented in a separate article.) Randomization was performed between April 2016 and March 2018.
The main outcome of COSMOS-Web was performance after 1 year of using Rei’s modified auditory verbal training. (ModRey) Test for immediate memory of 20 words. Secondary outcomes included change in ModRey immediate recall scores at 2 and 3 years, ModRey retention (the ratio of delayed recall to immediate recall that relates to entorhinal cortex function), and scores on novel object recognition and executive function tests. The tests were carried out through a web platform.
The intention-to-treat analysis included 3562 participants randomized to a multivitamin or placebo arm who completed at least one follow-up measurement at 1, 2, or 3 years. Demographic characteristics and baseline performance measures were similar between groups.
Tablet compliance was 94.4% at 6 months and 91.8% at 1 year. In a small subgroup, investigators evaluated blood samples and found increases in serum folic acid, vitamin B12, and 25(OH)vitamin D with multivitamins compared with placebo.
Compared to those who took placebo, participants who received multivitamin supplements experienced significantly greater improvement in ModRey working memory between baseline and 1 year. in the placebo group, it increased from 7.21 words to 7.65 words.
Mean memory improvement compared to placebo was sustained for at least 3 years after baseline. Secondary outcomes did not differ significantly between groups in any of the subsequent years.
In participants with a history of cardiovascular disease, the effect compared to placebo on the ModRey scale was higher at 1 year (mean difference 1.24 words, P= 0.009) than in people without underlying cardiovascular disease.
The data supports a growing body of evidence that nutrition may play a role in brain health.
“The finding that daily multivitamin supplementation improved memory in two separate studies of cognition in the randomized COSMOS trial is remarkable, suggesting that multivitamin supplementation holds promise as a safe, affordable, and affordable approach to protecting cognitive health in older adults,” co-author said. . Joanne Manson, MD, Brigham and Women’s Hospital, Boston.
The researchers acknowledged that the results may not apply to all older people. The sample consisted mainly of white educated adults. To participate in the study, people were required to have a computer and an Internet connection.
Judy George covers neuroscience and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, multiple sclerosis, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and much more. Follow
Information disclosure
The study was supported by grants from Mars Edge and the National Institutes of Health. Multivitamins were supplied by Pfizer (now Haleon).
Researchers have reported relationships with Pure Encapsulations, Pfizer, the Council for Responsible Nutrition, BASF, NIH, and the American Nutrition Society.
main source
American Journal of Clinical Nutrition
Link to source: Yeung LK, at al “Multivitamin Supplements Improve Memory in Older Adults: A Randomized Clinical Trial” Am J Clin Nutr 2023; DOI: 10.1016/j.ajcnut.2023.05.011.
Ultimatum: strange love is a Netflix series, half dating show, half social experiment. It involves five couples, and in each couple, one partner gave the other an ultimatum to continue the relationship and get married. Each couple then “breaks up” and they meet other actors for a week before choosing one person for a trial marriage. After three weeks of living together, each person then returns to their original partner for three weeks before deciding whether they want to stay with him, start a new relationship with their trial partner, or become single.
Each of the couples have different reasons for being on the show, from not being ready for marriage to not knowing if their partner really has what they need for a lifetime partnership. For Vanessa and Xander, their conflict is that Xander wants marriage and children, while Vanessa isn’t sure she wants to settle down and instead yearns for freedom.
Their personalities are also very different, as Xander is a little quieter and Vanessa likes to be the center of attention. And while the old adage “opposites attract” has kept their relationship going for four years, it looks like they both may be on the verge of breaking up.
When the experiment began, Vanessa expressed great excitement at the thought of dating different people, and she willingly began to connect with each of them. She has formed strong bonds with Lexie and Rae, who are exes, and while it seemed like she and Lexie were on the verge of moving forward, after Vanessa commented that she still doesn’t know if she wants something serious, well then revealed that she didn’t believe Xander would connect, Lexi questioned her reasons for being there, and their date ended on a sour note when Lexi told the cameras that she never wanted to see her again.
So what does this mean for Vanessa and Xander? Here’s what you need to know.
Vanessa and Xander from Ultimatum: strange love Are you still together?
Netflix
Soon after Vanessa and Lexi’s date, it’s time for all the singles to choose their new partners. Vanessa and Rae ended up choosing each other, but Lexie turned to her ex with an impassioned plea in which she revealed that she didn’t think Vanessa was on the show for the right reasons, and in her confession, she bluntly stated that Vanessa just wants to be famous The other members of the cast agreed, with Mildred even calling out Vanessa for saying “fuck off” to Xander across the table. Vanessa and Ray decided to move forward anyway, and their relationship seemed to be going well.
However, at the end of the fourth episode, Ray told Lexi that she and Vanessa slept together, which angered Lexi. At the next group event, the cast split into two groups and Lexi ran into Vanessa, who then confessed that she had no romantic intentions with Rae. At another group event, Ray confessed to Mal and she said that she believed Xander was unaware of the incident. The episode ended with a cliffhanger, but in previews for the rest of the season, Xander appears to be torn between his new partner Yoli and Vanessa. The next batch of episodes will premiere on May 31st, so we’ll have to wait until then to see if the longtime couple can handle it.
Temi Adebowale was previously an associate editor at Men’s Health covering shows such as Survivor, Peaky Blinders and Tiger King. Prior to working in entertainment at MH, she was a News Research Fellow writing news for Hearst Digital Media brands. They like Rihanna, StairMaster and tacos.
Gert-Jan Oskam walks with brain and spine implants and a backpack computer.
CHUV 2022/WEBER Gilles
A Dutchman who was paralyzed after breaking his neck can now walk on crutches after having an implant that allows his brain to send signals to his spine via a computer in his backpack.
Gert-Jan Oskam, 40, can now get up from a seated position, climb stairs and walk on uneven ground. “The stimulation will start as soon as I think about [taking] step, he says.
Oskar also found that even when the device was turned off, he could walk short distances using a wheeled walker. Gregoire Curtin from the Swiss Federal Institute of Technology (EPFL) in Geneva and his colleagues who developed the technology believe this may be because repetitive exercise stimulates the growth of nerve cells in the spine.
The brain implants are contained in two 5cm discs that rest on the surface of the brain, replacing two circles of bone taken from the skull. They communicate wirelessly with a helmet-style receiver that sends signals to a backpack computer. The computer then sends signals to stimulators inserted in Oscar’s spinal cord, which cause the leg muscles to move.
The system is an upgrade from the first version Oskam received five years ago that used only spinal electrodes. In this version, Oscar activated each step by making a small movement with his heel, which he could do because the accident hadn’t completely severed his spinal cord. Heel movements were detected by light motion sensors, and this caused the spinal implants to trigger semi-automatic stepping movements coordinated by networks of neurons in the lower spinal cord.
The resulting steps allowed Oskam to walk on level ground using wheeled walkers. “It was more like the walking motion of a robot,” Cortin says.
In 2021, Oskam received an upgraded brain implant. A few minutes after the operation, he was able to walk and this resulted in more natural movements. “It can regulate when the stimulation kicks in and how much. This makes the movement very smooth,” says Guillaume Charvet at the University of Grenoble-Alpes in France, another member of the team.
“Before, stimulation controlled me, but now I control stimulation with my thoughts,” Oscar says.
The brain-driven system also results in a wider variety of hip, knee, and ankle movements. Henri Lorach, member of the EPFL team. “He can access multiple functions.”
So far, a total of nine people have received single spinal implants by controlling their movements either with small residual leg movements, as Oscar did, or by pressing buttons on walkers. Some may now have an update.
The team also has permission to try the same approach to restore arm movement in people who are paralyzed from the neck down.
“This is great work,” he says. Zubair Ahmed at the University of Birmingham, UK. “What’s great is that they tie a lot of technology together.”
However, the system is still in the early stages of development and would be too expensive to be widely used for other people with spinal cord injuries, he says.
Fiber is the undigested portion of fruits, vegetables, and grains. A low fiber diet limits these foods in the diet. As a result, less undigested material passes through the colon, and stools become less bulky.
A low fiber diet may be recommended for a number of conditions or situations. It is sometimes referred to as a limited fiber diet.
target
Reasons your healthcare provider may prescribe a low-fiber diet include:
You have a narrowing of the intestines. It may be due to a tumor or an inflammatory disease such as Crohn’s disease and ulcerative colitis.
You’ve had bowel surgery.
You are undergoing treatment that damages or irritates the digestive system. For example, radiation can cause irritation.
Low-fiber diets are usually temporary. You can usually start adding more fiber to your diet after a short amount of time.
Diet details
A low-fiber diet limits the types of vegetables, fruits, and grains you can eat. Some of the foods that are allowed on a low fiber diet include milk, cheese, yogurt, meat, fish, and eggs. People with lactose intolerance should avoid milk and dairy products if they cause stomach pain or diarrhea.
The ability to digest food varies from person to person. A health professional may recommend a more or less restricted diet depending on the reasons for which it is being used.
If you are on a low fiber diet, be sure to read food labels. Foods you may not expect may contain fiber. For example, yogurt, ice cream, cereal, and even some drinks can contain fiber. Look for foods that contain no more than 1-2 grams of fiber per serving.
Avoid these foods and foods made from them:
Nuts, seeds, dried fruits and coconut.
Whole grains, popcorn, wheat germ and bran.
Brown rice, wild rice, oatmeal, muesli, crushed wheat, quinoa, bulgur and barley.
Dried beans, baked beans, lima beans, peas and lentils.
Strong peanut butter.
Fruits and vegetables, except as noted below.
Choose these products:
Tender meats, fish and poultry, ham, bacon, shellfish and lunch meats.
Eggs, tofu and creamy peanut butter.
Dairy products if tolerated.
White rice and pasta.
Baked goods made from refined wheat or rye flour, such as bread, cookies, pancakes, waffles, bagels, salty and crackers.
Hot and cold cereals containing less than 2 grams of dietary fiber per serving. Cereals made from rice cereal are often very low in fiber.
Canned or well cooked potatoes, carrots and green beans.
Regular tomato sauce.
Vegetable and fruit juices.
Bananas, melons, applesauce and canned peaches (no skins).
Butter, margarine, oils and salad dressings without seeds.
A typical menu might look like this:
Breakfast
Corn flakes with milk.
White toast, creamy peanut butter, jelly.
Fruit juice.
Coffee.
afternoon tea
Yogurt without seeds.
Water or other drink.
afternoon tea
Sandwich with turkey on white bread with mayonnaise.
Tomato soup.
canned peaches.
Milk or other drink.
afternoon tea
Cheese slices.
Salted crackers.
Water or other drink.
Dinner
Baked fish.
Butter mashed potatoes.
Boiled carrots.
applesauce.
Milk or other drink.
Prepare all foods so that they are soft. Good cooking methods include simmering, simmering, simmering, steaming, and rising. Baking or microwave cooking in a sealed container is another option.
You may have fewer bowel movements and smaller stools on a low-fiber diet. To avoid constipation, you may need to drink more fluids. Drink plenty of water unless your healthcare provider tells you otherwise.
results
Eating a low fiber diet will limit your intestinal motility. It may help reduce diarrhea or other symptoms such as stomach pain. After a short time, you will be able to slowly reintroduce fiber into your diet again.
risk
Because a low-fiber diet limits what you can eat, it can be difficult to meet your nutritional needs. You should only follow a low-fiber diet for as long as your health care provider tells you to.
If you need to follow this diet for a longer period of time, please consult a registered dietitian. A dietitian can help make sure you meet all of your nutritional needs.
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May 24, 2023
Govind M. et al. Global recommendations of the World Gastroenterological Organization: diet and intestines. Journal of Clinical Gastroenterology. 2022; doi:10.1097/MCG.0000000000001588.
Low fiber foods. American Cancer Society. https://www.cancer.org/treatment/survivorship-during-and-after-treatment/coping/nutrition/low-fiber-foods.html. As of January 7, 2023
Diet with limited fiber. Nutrition guide. Academy of Nutrition and Dietetics. association. https://www.nutritioncaremanual.org/. As of January 7, 2023
Food therapy with limited fiber (13 grams). Nutrition guide. Association of the Academy of Nutrition and Dietetics. https://www.nutritioncaremanual.org/. As of January 7, 2023
Maida M. et al. Predictors of adequate bowel cleansing for colonoscopy in the elderly: a retrospective analysis of a prospective cohort. Diagnostics (Basel). 2022; doi:10.3390/diagnostics12112867.
Feldman M. et al., eds. Power management. In: Diseases of the gastrointestinal tract and liver by Sleizenger and Fordtran: pathophysiology, diagnosis, treatment. 11th ed., Elsevier; 2021. https://www.clinicalkey.com. As of January 7, 2023